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The Comparative Study of the Effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in Treatment of Children with Dyspepsia

机译：西咪替丁，雷尼替丁，法莫替丁和奥美拉唑治疗儿童消化不良的疗效比较研究

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Background. Functional dyspepsia is a common chronic disorder with non specific upper abdominal pain or discomfort. Different approaches with anti-secretory, spasmolytic, prokinetic and anti-inflammatory effects and most preferably reduction of visceral hypersensitivity seem logical. In this study, we compared the effectiveness of the four most drugs used for treatment of dyspepsia in children. Methods. 169 patients between 2 to 16 years old that 47.3% was male and 52.7% was female were enrolled in this clinical trial study by the diagnosis of functional dyspepsia. Then for each patient one of the drugs; Omeprazole, Famotidine, Ranitidine or Cimetidine was administered, for a period of 4 weeks. Patients were followed after 2 and 6 weeks from the beginning of the treatment. Results. The distribution of drugs between these patients were including; 21.9% with Cimetidine, 21.3% with Famotidine, 30.8% with Omeperazole and 26% with Ranitidine that the proportion of patients with all symptoms relief were: 21.6% for Cimetidine, 44.4% for Famotidine, 53.8% for Omeprazole and 43.2% for Cimetidine (P = .024). In followups within 2 and 6 weeks after beginning medical therapy, no side effects due to drugs were seen. Conclusion. If a cure is defined as all symptoms relief after a period of 4 weeks treatment, our findings showed that Omeperazole are superior to Ranitidine, Famotidine, and Cimetidine for management of functional dyspepsia.
机译：背景。功能性消化不良是一种常见的慢性疾病，具有非特异性的上腹部疼痛或不适。具有抗分泌，解痉，促动力和抗炎作用以及最优选降低内脏超敏性的不同方法似乎是合乎逻辑的。在这项研究中，我们比较了四种用于治疗儿童消化不良的药物的有效性。方法。该临床试验通过功能性消化不良的诊断招募了169例2至16岁的患者，其中男性占47.3％，女性占52.7％。然后为每个患者使用其中一种药物；给予奥美拉唑，法莫替丁，雷尼替丁或西咪替丁4周。从治疗开始2周和6周后随访患者。结果。这些患者之间的药物分布包括：西咪替丁21.9％，法莫替丁21.3％，奥美拉唑30.8％，雷尼替丁26％，所有症状缓解的患者比例分别为：西咪替丁21.6％，法莫替丁44.4％，奥美拉唑53.8％和西咪替丁43.2％（ P = .024）。在开始药物治疗后2周和6周内的随访中，未观察到药物引起的副作用。结论。如果将治愈定义为经过4周治疗后所有症状均得到缓解，我们的研究结果表明，奥美拉唑在功能性消化不良的治疗方面优于雷尼替丁，法莫替丁和西咪替丁。

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